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| April 30 | ||
|---|---|---|
 INV | Nolson comes out of retirement and joins. | |
 TEX | General moves to starting roster. iLLeY moves to substitute. | |
 UA.NA | Mayhem (Coach) joins. | |
 TN | Mayhem (Coach) leaves. | |
| TN | General leaves. | |
 Ultra Academy NA, Big boys,  Louisville Red Wolves, and  WhateverItTakes qualify for CDC North America 2022 Elite Stage 3. | ||
dos tontos y medio,  Team Invincibles,  Sileo Synes, and  Mystaken Esports qualify for CDC Europe 2022 Elite Stage 3. | ||
| April 29 | ||
 OMG | Rage joins. | |
 SB | EriKBooM, SupeR, YaKo, and Sikotik (Coach) leave. | |
 RØK.A | JurNii leaves. | |
 WIT | Neptune joins. oJohnny leaves. | |
 NY | Neptune moves to substitute. | |
| April 28 | ||
 VOID | Imagine, JamesJHR, ManOfChicken, and Middoh join. | |
 MF | ManOfChicken (Assistant Coach) leaves. | |
 BSC | Traixx joins. | |
| April 27 | ||
 VAL | Team signs roster of  uT Crew. Phantomz, Wrecks, Xotic, and Yeez join. | |
 uTC | Roster is signed by  Valor Esports. Phantomz, Wrecks, Xotic, and Yeez leave. | |
| MIN | Havok joins. MajorManiak moves to substitute. | |
| TN | Havok leaves. | |
 STA | Cryptic, Kyzer, Mind, Ulisses, VinnY (Head Coach), Atom (Coach), and Viiox (Coach) leave. | |
| April 27 (approx.) | ||
| TN | Breszy leaves. | |
| April 26 | ||
| STA | GBursted (S&D Analyst) leaves. | |
| April 25 (approx.) | ||
 3KG | Pajson (Coach) joins. | |
| WIT | Pajson (Coach) leaves. | |
| April 25 | ||
| PRES | Censor, Ghosty, Seany, 7omm1 (Coach), and Rayless (Analyst) leave. | |
| PRES | Wand leaves. | |
 WaR | Denza, Maple, WarDy, and Weeman join. | |
| Call of Duty League Ruleset v1.4 is released. | ||
| April 24 | ||
 ESG.B | Fame, GodRx, Pandur, Pentagrxm, and Koa Galves (Coach) join. | |
  18andcracked  WhateverItTakes in the The Clutch Cup. | ||
 Los Angeles Guerrillas TiberiousKhan in the Call of Duty League 2022 - Resurgence. | ||
| April 22 | ||
 18C | Assault, Exceed, Noysii, Welly, Arian (Coach), and Cheek (Analyst) join. | |
 INF | Assault, Classic, Exceed, Welly, Arian (Coach), and Cheek (Analyst) leave. | |
| uTC | Phantomz, Wrecks, Xotic, and Yeez join. | |
 UYU | Phantomz and Wrecks leave. | |
 TB | Hollow, Jintroid, Mock, Venom, Veohz (Head Coach), and Sharp (Analyst) join. | |
| UYU | Jintroid and Tisch (Head Coach) leave. | |
| 3KG | Dak, Gusify, Volants, and Whiz join. Proto, Zinx, and DawsonVoid (Coach) leave. | |
 ExM7 | ProMR leaves. | |
| April 20 (approx.) | ||
 VIT | Moonscope retires. | |
| April 20 | ||
 MTK | Shaun joins. | |
| April 19 (approx.) | ||
| WaR | Diamondcon, Royalty, Venom, and Abas (Coach) leave. | |
| April 18 | ||
| STA | Atom (Coach) joins. | |
| 3KG | Brack leaves. | |
| April 15 | ||
| WIT | 2ReaL, Brack, oJohnny, Prolute, and Pajson (Coach) join. | |
| WaR | Prolute leaves. | |
| UYU | oJohnny leaves. | |
| April 12 | ||
 ALPH | Bink, Gusify, Volants, and Whiz leave. | |
 RT | Watson retires. | |
| April 12 (approx.) | ||
| RT | Chaaxter, Keza, and Mythix leave. | |
| April 10 (approx.) | ||
| MTK | Magxck (Coach) leaves. | |
 BCG | Hamza leaves. | |
| April 10 | ||
 LRW | Darksived joins. Spida leaves. | |
| STA | GBursted (S&D Analyst) joins. | |
| STA | Mind joins. | |
| TOR | Scrappy joins as substitute. | |
| April 9 | ||
 SPARTANgg  Nixuh in the Mettlestate ROG Invitational. | ||
 F/A | Sukry renames to Aaron. | |
| April 8 | ||
 GHC | Kohvz, Levcitys, Lithium, and Rahil leave. | |
| April 7 | ||
| INV | Shaun leaves. | |
| Fifakill & Jukeyz ScummN & UnRationaL in the BoomTV x TimTheTatman 2v2 Kill Race. | ||
| BCG | Noysii and Xotic leave. | |
| April 6 | ||
 M7 | Denza, Maple, WarDy, and Weeman leave. | |
| STA | 2ReaL leaves. | |
| April 6 (approx.) | ||
 VTZE | KidzZ, Nevo, Rezzy, and Vitxll leave. | |
| MTK | Aroma leaves. | |
| April 5 | ||
 FS | Yeez leaves. | |
 NT | Darksived leaves. | |
| April 4 | ||
 dT.B | Bafundo, Bandi, Ethan2Nice, and Proffecide leave. | |
 dT.P | 0reo, Bowser, Hxrman, and PDasson leave. | |
| NT | FarMa, Rixsrr, and Wisdom leave. | |
| OUTM | Sypnatik leaves. | |
 DG | BuNNa and Frex leave. | |
| COAS | Kezextt (Coach) leaves. | |
 TN | Apexcitys, Decimate, and TrenchUnit leave. | |
| FS.B | Paraylxsis and Revan4k leave. | |
| BCG | Radial leaves. | |
 sX.R | Apox, Cruelty, Herby, and TTinyy leave. | |
 DTO | Dak leaves. | |
| April 4 (approx.) | ||
| DTO | Hollow, Mind, Mock, Veohz (Head Coach), and Sharp (Analyst) leave. | |
 SMOG | Hitmxn and Infinit leave. | |
| FS | Fame, GodRx, Pandur, Yeez, and Koa Galves (Coach) leave. | |
| ExM7 | KaTaNi, Mochila, ProMR, Teskiy, and Cade Thompson (Coach) leave. | |
| April 3 | ||
| OMG | CRUSH leaves. | |
| 3KG | Pentagrxm leaves. | |
| Spart is awarded the Call of Duty League 2022 - Major 2 MVP. | ||
Los Angeles Guerrillas  Atlanta FaZe in the Call of Duty League 2022 - Major 2. | ||
 Blacklist Ultimate  DG Esports in the Garena Invitational 2022. | ||
 Ultimate Divinus  Daivo Lady in the Garena Invitational 2022 Girls. | ||
Ultra Academy NA  M7 x Electrify in the CDC Minnesota Open 2022. | ||
| April 2 | ||
 OU | Remzii joins. | |
| VAL | Archivs, Infamous, MRuiz, and Zyyral leave. | |
| April 1 | ||
 iNCO | Lucaszin joins. Glda7 (Player to Coach) changes position. Araujo leaves. | |
| ALPH | Volants joins. KaTaNi leaves. | |
| ExM7 | KaTaNi joins. Volants leaves. | |
 BOS | Censor (Content Creator) joins. | |
| BCG | Hamza and Newb (Coach) join. Welly leaves. | |
| April 1 (approx.) | ||
| MTK | Higgy leaves. | |